January 8 – In the final battles of the Jacobite Rising, Bonnie Prince Charlie occupies Stirling. On January 17 at the Battle of Falkirk, British Government forces are defeated by Jacobite forces. On April 16, the Battle of Culloden brings an end to the Jacobite Rising. On August 1, the wearing of the kilt is banned in Scotland by the Dress Act. On August 18 – Two of the four rebellious Scottish lords, Earl of Kilmarnock and Lord Balmeniro, are beheaded in the Tower. On September 20, Bonnie Prince Charlie flees to the Isle of Skye.
October 22 - The College of New Jersey (Princeton University) is chartered.
October 28 – An earthquake demolishes Lima and Callao, Peru.
In 1746, Governor Gabriel Johnston of the Royal Colony of North Carolina moves to the province's largest and most prosperous city of New Bern, which replaces Edenton as the capital of North Carolina.
